Jeste li znali da je Avon prva kompanija koja je počela koristiti stabilan retinol u svojim kozmetičkim proizvodima? U Avon laboratorijima u Suffernu, Big apple znanstvenici su sada došli i do još većeg otkrića – Protinola – koji paralelno potiče proizvodnju two tipa kolagena i tako dodatno učvršćuje i obnavlja kožu lica.
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Summary in English, French Objective: Facial skin undergoes main structural and purposeful alterations as a result of intrinsic and extrinsic factors. The objective of the present function will be to show L-4-thiazolylalaine (L4, Protinol), a non-proteinogenic amino acid demonstrated to stimulate the creation of dermal proteins by fibroblasts, is another efficacious topical ingredient for seen signs of ageing. Techniques: In vitro research working with 3D human skin tissue products were being executed to show alterations in protein and gene expression of key dermal markers in samples handled with 0.three% L4 in comparison with vehicle control. In vivo analysis of skin turnover was calculated in volunteers right after procedure with L4 compared to retinol. Skin biopsies (n = thirty) have been taken to analyze epidermal and dermal modifications in instances handled with L4 and when compared to retinol. At last, a clinical analysis (n = 28) was executed to assess the efficacy of L4 over a foundation formulation applying different ageing parameters inside a population of girls 46-66 a long time previous with mild-to-moderate wrinkles. Results: In vitro studies on 3D tissues exhibited major changes in the dermal matrix through an increase in HA and Professional-collagen I creation along with a minimize in the expression of inflammatory genes. In vivo biopsy reports shown that L4 and retinol independently improved epidermal thickness and collagen remodelling significantly additional when compared with the base method. Clinical analysis showed firmer and smoother skin at day 28 article-treatment with L4 more than the vehicle Handle devoid of creating Uncomfortable side effects like redness or discomfort. Summary: L4 is a novel, multi-practical component which offers a outstanding option to now available systems for increasing epidermal and dermal parameters that improve during ageing and photodamage. Objectif: La peau du visage est sujet à des changements majeurs structuraux et fonctionnels dus à des facteurs intrinsèques et extrinsèques. Dans cette étude, nous montrons que l'acide aminé non-protéinogène L-4-thiazolylalanine (L4, Protinol) est une different intéressante pour une application topique.
ProtinolTM je jedinstvena kombinacija aminokiselina koja pomaže u održavanju savršene ravnoteže kolagena. Pored kolagena tipa I, koji koži daje elastičnost, izuzetno je važan i kolagen tipa III, koji je najzastupljeniji u bebinoj koži i značajan je za formiranje i funkcionisanje kolagena tipa I.
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Avonovi znanstvenici otkrićem Protinola poboljšavaju obnavljanje kolagena i uvode nas u novo doba njege kože tijekom starenja.
Collagen III is such as matrix that Collagen I binds to as cleansing scrub well as ratio of Collagen III to I decreases as we experienced. This transforming ratio is believed to add to the shifting appear and feel of skin after some time. Having the ability to promote the production of Collagen III and I is exactly what helps make Protinol™ so special.
Right up until now, only collagen one continues to be correctly restored via topical skincare, but without the matrix of ‘little one collagen’- the impact is negligible. Avon’s new breakthrough patented component*, Protinol™, works to restore both collagen 1 AND collagen three, bringing them closer to that exceptional ratio located in baby skin.
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Već od detinjstva, njihov balans prirodno opada i zato je maksimalna koncentracija patentiranog ProtinolaTM u Anew Power Shot ampulama kreirana da podstakne oba i na taj način koži vrati mladalački kolagen i njen prirodan balans.
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Collagen three (usually generally known as ‘baby collagen’, thanks to its presence in toddler skin) presents a framework that collagen 1 binds to. The 2 different types of collagen need one another to operate proficiently.